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KMID : 0356620120270030232
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Journal of Korean Society of Endocrinology
2012 Volume.27 No. 3 p.232 ~ p.236
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A Case of Adipsic Hypernatremia Associated with Anomalous Corpus Callosum in Adult with Mental Retardation
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Kim Boo-Gyoung
Kim Ka-Young
Pack Yun-Jung
Yang Keun-Suk
Kim Ji-Hee
Jung Hee-Chan
Nam Hee-Chul
Kim Young-Ok
Yun Yu-Seon
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Abstract
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Adipsic hypernatremia cause chronic hyperosmolality and hypernatremia through a combination of impaired thirst and osmotically stimulated antidiuretic hormone secretion. This syndrome can be grouped together as disorders of osmoreceptor dysfunction due to the various degrees of osmoreceptor destruction related with different types of intracranial lesions around the anterior hypothalamus, consistent with the location of primary osmoreceptor cells. Adipsic hypernatremia, associated with developmental disorder of corpus callosum, is very rare. Most cases are diagnosed at infancy and early childhood; the replacement of desmopressin is necessary. Herein, we report adipsic hypernatremia associated with anomalous corpus callosum in adult with mental retardation; they were treated with only free water without desmopressin.
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KEYWORD
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Corpus callosum, Hypernatremia, Thirst
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